ARA-290 (Cibinetide) Dosing, Need to Know Information, Safety, Stacks, Dosing Calculator and more!
How much do I take? Is this right for me? How do I use it? Is it safe? How do I know it's working? Compound Profile Scientific & Efficacy Data C51H84N16O21 Molecular Formula 1257.31 g/mol Molecular Weight Approximately 1-2 hours in circulation, but cellular ef
How much do I take?
Is this right for me?
How do I use it?
Is it safe?
How do I know it's working?
Compound Profile
Scientific & Efficacy Data
C51H84N16O21
Molecular Formula
1257.31 g/mol
Molecular Weight
Approximately 1-2 hours in circulation, but cellular effects last much longer
Half-Life
Subcutaneous: ~100% (complete absorption); Intravenous: Immediate
Bioavailability
1208243-50-8
CAS #
91810664
PubChem ID ↗
Developed By · 2008
Araim Pharmaceuticals Research Team
Araim Pharmaceuticals
Primary Benefits
ARA-290 actively regrows small nerve fibers that die from diabetes, neuropathy, or injury. Studies show real improvements in nerve density on corneal imaging.
Reduces neuropathic pain through both nerve repair and anti-inflammatory pathways. Users report decreased shooting pain and burning sensations.
Protects pancreatic cells, organs, and tissues from stress damage. Works especially well in diabetes where tissues face constant oxidative harm.
Amino Acid Sequence
Dosing
How muchdo I take?
Subcutaneous: A small injection into the fatty layer just under the skin — the same way insulin is given.
Bioavailability High — most of the dose reaches your bloodstream, just more gradually than an IV.
Starting Dose
1 mg
Frequency
Once daily
Duration
28 days
Lowest dose tested in the phase 2 sarcoidosis nerve study. A good starting point while watching how the body responds [1].
Standard Dose
4 mg
The 4 mg dose gave the strongest nerve-fiber regrowth and pain relief in the trial — better than the higher 8 mg dose [1][2].
Advanced Dose
8 mg
Highest daily dose studied in the sarcoidosis trial. It was safe but did not beat 4 mg for nerve outcomes [1].
Timing
Best time to take
Administer ARA-290 (Cibinetide) at the same time each day (or on the same day each week for weekly injections). Many users prefer morning or evening administration. Pick a time you'll remember consistently.
With food?
ARA-290 (Cibinetide) injections can be given regardless of meal timing. However, if GI effects occur, administering on an empty stomach or with a light meal may help reduce discomfort.
If stacking
ARA-290 (Cibinetide) should be used as directed by your healthcare provider. If combining with other medications or supplements, discuss potential interactions with your provider. Avoid combining with compounds that have overlapping mechanisms unless specifically guided by a medical professional.
Adjusting Your Dose
Increase if
+You've tolerated the current dose for the recommended period without significant side effects
+Therapeutic goals haven't been met at the current dose level
+Your healthcare provider recommends dose escalation based on your response
+Lab work or clinical assessments support a higher dose
Decrease if
-Side effects are bothersome or impacting daily life despite management strategies
-You experience any signs of an adverse reaction
-Lab results indicate the need for dose reduction
-Your healthcare provider recommends a lower dose based on your response
Signs of right dose
✓Therapeutic goals being met with minimal side effects
✓Stable and consistent response to treatment
✓Lab values or clinical markers trending in the right direction
✓Good tolerance with manageable or absent side effects
Dosing Calculator
Calculate Your Exact Dose
Step 1: Peptide Weight
Find the weight printed on your peptide vial label
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The peptide weight is printed on the label
The weight is on the label
Select Weight
Look for a number followed by 'mg' on the vial label (e.g., 5mg, 10mg)
Suitability
Is thisright for me?
Best For
Treating small fiber neuropathy
ARA-290 (Cibinetide) is particularly well-suited for individuals focused on treating small fiber neuropathy. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Managing neuropathic pain from diabetes or sarcoidosis
ARA-290 (Cibinetide) is particularly well-suited for individuals focused on managing neuropathic pain from diabetes or sarcoidosis. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Supporting nerve regeneration after injury
ARA-290 (Cibinetide) is particularly well-suited for individuals focused on supporting nerve regeneration after injury. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Reducing chronic inflammation
ARA-290 (Cibinetide) is particularly well-suited for individuals focused on reducing chronic inflammation. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Consider Alternatives If
Goal: Alternative approaches for healing & recovery support
Consider: Consult your healthcare provider for alternatives to ARA-290 (Cibinetide) based on your specific needs and medical history
Goal: Alternative healing peptides
Consider: BPC-157, TB-500 (Thymosin Beta-4), GHK-Cu
Goal: Non-peptide recovery options
Consider: Platelet-Rich Plasma (PRP), Collagen supplements, Physical therapy
Who Should Avoid
Do not use if
×Polycythemia vera or erythrocytosis
×Uncontrolled hypertension
×Pregnancy or breastfeeding
×Known hypersensitivity to peptides
×Concurrent use with certain cancer medications
Use with caution if
!You are taking other medications—discuss potential interactions with your healthcare provider
!You have a history of liver or kidney disease
!You are elderly or have multiple medical conditions
!You are planning surgery in the near future—inform your surgeon about ARA-290 (Cibinetide) use
!You have any chronic health conditions that require regular monitoring
Not Sure?
Compare ARA-290 (Cibinetide) with similar peptides to find the best fit for your goals.
Administration
How do Iuse it?
Reconstitution
What you need
•ARA-290 (Cibinetide) vial (lyophilized powder or solution)
•Bacteriostatic water or sterile sodium chloride for reconstitution
•Alcohol swabs for cleaning vial tops and injection sites
•Appropriately sized syringes with fine-gauge needles (27-30 gauge)
•Sharps disposal container
Example
Add the recommended volume of bacteriostatic water to the ARA-290 (Cibinetide) vial. Gently swirl (do not shake) until the powder is fully dissolved. The resulting solution should be clear. Calculate your individual dose based on the concentration and your prescribed amount.
Your dose of ARA-290 (Cibinetide) is determined by your healthcare provider. Using an insulin syringe marked in units, draw up the exact amount prescribed. For example, if the reconstituted concentration is 1mg/mL and your dose is 0.5mg, draw up 0.5mL (50 units on an insulin syringe). Always double-check calculations before injection.
Injection
Route
Subcutaneous injection (into the fatty tissue just under the skin)—allows for consistent absorption and can be self-administered at home after proper training
Best sites
•Abdomen (stomach area)—at least 2 inches from the belly button, most popular choice for self-injection
•Front of thighs—middle to upper portion of the outer leg
•Back of upper arm—outer area (may need assistance from another person)
Technique
1.Wash your hands thoroughly with soap and water before handling supplies
2.Clean the injection site with an alcohol swab and let it air dry completely
3.Pinch a fold of skin at the chosen injection site
4.Insert the needle at a 45-90 degree angle (depending on needle length and body composition)
5.Inject the medication slowly and steadily over 5-10 seconds
6.Release the skin fold and remove the needle, applying gentle pressure with a clean swab
7.Rotate injection sites to prevent tissue irritation or lipodystrophy
8.Dispose of the needle safely in a sharps container—never recap or reuse needles
Storage
Before reconstitution
Store ARA-290 (Cibinetide) in the refrigerator at 36-46°F (2-8°C) in its original packaging. Protect from light and moisture. Do not freeze. Check the expiration date before use. Some formulations may be stored at room temperature for limited periods—check your specific product labeling.
After reconstitution
Once reconstituted, ARA-290 (Cibinetide) should be kept refrigerated at 36-46°F (2-8°C) and used within the timeframe specified on your product labeling (typically 14-28 days). Label the vial with the reconstitution date. Do not use if the solution appears cloudy, discolored, or contains particles.
Signs of degradation
Solution appears cloudy, discolored, or contains visible particles (should be clear)
Product has been exposed to temperatures outside the recommended storage range
Product has been frozen (unless specifically designed for freeze-thaw stability)
Expiration date has passed or reconstituted solution has exceeded its use-by date
Unusual odor, color change, or visible contamination
Sample Daily Schedule
As prescribed (once daily)
As prescribed by your healthcare provider injection
Site: Subcutaneous injection—rotate sites if applicable
Maintain a consistent schedule for optimal results with ARA-290 (Cibinetide). Set reminders if needed. If you miss a dose, follow your healthcare provider's instructions—do not double up on doses to compensate.
Safety
Is itsafe?
Safety Profile
ARA-290 is a synthetic innate repair receptor agonist that has completed Phase 2 clinical trials for small fiber neuropathy and is under active development. Animal toxicology studies show a good safety margin with no organ damage or cytotoxicity at doses far exceeding therapeutic levels. Early clinical data from Phase 2 trials demonstrate tolerability with mild injection site reactions and transient headache as primary concerns. However, immunogenicity remains a potential risk with repeated dosing of synthetic peptides, requiring anti-drug antibody monitoring. Long-term safety data beyond 12 weeks does not yet exist.
Evidence comes from preclinical toxicology studies, Phase 1 dose-escalation and safety data, and Phase 2 efficacy trials in small fiber neuropathy patients. The phase 2 trial enrolled 127 patients with a primary endpoint of safety and tolerability. No serious adverse events directly attributable to ARA-290 were reported in early studies. Data suggests good safety at doses up to 1 mg subcutaneously twice weekly, but longer-term outcomes and immunogenicity assessments continue.
Common Side Effects
Experienced by some users
Injection Site Reactions
Redness, mild swelling, or bruising at injection site lasting a few hours to a day
Management: Rotate injection sites, apply ice pack after injection, massage gently to improve absorption
Headache
Mild to moderate headache typically in first few hours after injection
Management: Stay hydrated, rest in a quiet space, over-the-counter pain reliever if needed
Dizziness
Brief dizziness or lightheadedness, especially when standing up quickly
Management: Rise slowly from sitting or lying, avoid sudden movements, inform your doctor if persistent
Less Common
•Elevated Blood Pressure
•Fatigue
These typically resolve with continued use or dose adjustment.
Stop and Seek Help If
×Severe or worsening side effects that don't improve with dose adjustment or supportive care
×Signs of an allergic reaction—rash, hives, swelling, or difficulty breathing
×Your healthcare provider recommends discontinuation based on your clinical response
×Development of any new medical condition that may be contraindicated with ARA-290 (Cibinetide)
×Pregnancy or planning to become pregnant (unless specifically approved for use during pregnancy)
×Abnormal lab results or clinical markers that suggest adverse effects
ARA-290 (Cibinetide) should only be started, adjusted, or discontinued under medical supervision. This information is for educational purposes only and does not replace professional medical advice. Never stop a prescribed treatment without consulting your healthcare provider first, as abrupt discontinuation may have consequences.
Interactions
With other peptides
✓Enhances antioxidant protection and reduces inflammation to complement nerve regeneration
✓Fat-soluble form of B1 vitamin that supports nerve function alongside ARA-290's regenerative effects
✓Essential for nerve health and myelin formation, works synergistically with nerve repair
With medications
!Erythropoietin (EPO) - Both activate similar pathways; combining could cause excessive red blood cell production
!Uncontrolled antihypertensive medications - May cause dangerous blood pressure fluctuations
!Anticoagulants at high doses - May increase thrombosis risk
With supplements
✓Multivitamins - Generally safe to take alongside ARA-290 (Cibinetide). Space doses apart if taking oral formulations to ensure optimal absorption.
✓Electrolyte supplements - Helpful if experiencing any GI side effects that could lead to dehydration. Safe to combine.
Effectiveness
Does itwork?
Evidence Level
Moderate human trials
What to Expect
Week 1-2: Initial Response (First two weeks)
What you might notice
•You may notice improved energy, better sleep, or mild improvement in pain
•Injection site reactions are most common now
•Your body's repair systems are just starting to activate
What's normal
•Initial response to ARA-290 (Cibinetide) is beginning at the cellular level
•Different individuals experience ARA-290 (Cibinetide)'s onset at different rates
•Transient systemic effects from initial ARA-290 (Cibinetide) exposure are common
What's next
→Maintain consistent ARA-290 (Cibinetide) administration as prescribed
→Document subjective effects and physical markers daily
→Schedule a check-in with your provider about initial observations
Week 3-8: Noticeable Changes (Weeks 3-8)
•Pain reduction becomes more apparent
•Inflammation starts decreasing
•Some users report better blood sugar control
•Nerve regeneration is happening but may not be felt yet
•ARA-290 (Cibinetide) is now achieving steady-state pharmacokinetics
•Measurable changes aligned with ARA-290 (Cibinetide)'s mechanism may appear
•Initial adjustment effects typically resolve by this point
→Maintain ARA-290 (Cibinetide) dosing exactly as established
→Track progress toward intended outcomes in detail
→Review lab work or biomarker changes with your healthcare team
Week 9-16: Significant Improvement (Weeks 9-16)
•Neuropathic pain noticeably reduced
•Increased sensation in feet (if neuropathy was present)
•Better energy and mood
•Healing effects becoming measurable
•ARA-290 (Cibinetide) has achieved stable, long-term homeostatic integration
•Sustained efficacy of ARA-290 (Cibinetide) remains consistent
•Chronic ARA-290 (Cibinetide) effects remain stable and predictable
→Maintain your established ARA-290 (Cibinetide) protocol for sustained benefits
→Continue periodic monitoring to confirm ARA-290 (Cibinetide) efficacy
→Review comprehensive ARA-290 (Cibinetide) response with your provider
Month 4+: Full Benefits Realized (4+ months)
•Maximum nerve fiber regrowth visible on corneal imaging
•Sustained pain reduction
•Improved daily function and quality of life
•Benefits continue with ongoing treatment
•Full therapeutic effects of ARA-290 (Cibinetide) are well-characterized at this point
•Maintenance of ARA-290 (Cibinetide)'s therapeutic effects is typical
•Tolerance patterns with ARA-290 (Cibinetide) are generally stable over months
→Comprehensive assessment of ARA-290 (Cibinetide) efficacy should be conducted
→Discuss long-term continuation, cycling, or protocol modifications
→Continue regular monitoring of relevant biomarkers or symptoms
Signs It's Working
Treatment Response
✓Improvement in the primary symptoms or condition being treated
✓Positive changes in relevant lab values or clinical markers
✓Consistent, stable response to ARA-290 (Cibinetide) over time
✓Reduction in symptom frequency or severity
General Well-being
✓Improved energy levels and daily functioning
✓Better quality of life related to the treated condition
✓Manageable or absent side effects indicating good tolerance
✓Positive feedback from healthcare provider during check-ups
Not Seeing Results?
Common reasons
•Not at therapeutic dose yet—initial doses are for building tolerance, not maximum effect
•Insufficient time at target dose—most compounds need several weeks to show full benefits
•Inconsistent dosing schedule—regular, consistent use is crucial for optimal results
•Individual variation in response—genetics, metabolism, and other factors affect outcomes
•Underlying conditions or medications interfering with absorption or effectiveness
•Improper storage leading to degraded product—always verify proper storage conditions
Key Research
[1]"ARA 290, a nonerythropoietic peptide engineered from erythropoietin, improves metabolic control and neuropathic symptoms in patients with type 2 diabetes"
Brines M, et al., 2015
Finding: ARA-290 treatment resulted in significant improvement of neuropathic pain in diabetic patients along with increased corneal nerve fibers. The peptide showed disease-modifying properties with long-lasting beneficial effects on both pain-related and non-pain-related symptoms.
[2]"Cibinetide Improves Corneal Nerve Fiber Abundance in Patients With Sarcoidosis-Associated Small Nerve Fiber Loss and Neuropathic Pain"
Culver DA, et al., 2017
Finding: Cibinetide at 4 mg daily significantly increased corneal nerve fiber area by 697 μm², along with increased regenerating intraepidermal fibers. Pain improved significantly in all groups, with changes in nerve fiber abundance correlating with improvements in walking distance and pain severity.
[3]"Corneal nerve fiber size adds utility to the diagnosis and assessment of therapeutic response in patients with small fiber neuropathy"
Brines M, et al., 2018
Finding: Corneal nerve fiber area measurements proved useful for tracking therapeutic response to ARA-290 treatment in neuropathy. The metric showed quantifiable changes in nerve morphology and provided superior sensitivity to identify nerve repair compared to skin biopsy.
[4]"Erythropoietin-derived nonerythropoietic peptide ameliorates experimental autoimmune neuritis by inflammation suppression and tissue protection"
Liu Y, et al., 2014
Finding: ARA 290 greatly improved recovery from autoimmune nerve inflammation by promoting nerve regeneration and remyelination while suppressing inflammation. The treatment increased protective regulatory T cells and reduced pro-inflammatory immune responses.
[5]"ARA 290 for treatment of small fiber neuropathy in sarcoidosis"
van Velzen M, et al., 2014
Finding: ARA 290 treatment was associated with significant improvements in neuropathic pain, increased corneal nerve fibers, improved sensory thresholds, and better quality of life in sarcoidosis patients. The excellent safety profile combined with disease-modifying properties makes it promising for treating this orphan disease.
[6]"Safety and efficacy of ARA 290 in sarcoidosis patients with symptoms of small fiber neuropathy: a randomized, double-blind pilot study"
Heij L, Niesters M, Swartjes M, et al., 2012
Finding: Intravenous ARA 290 at 2 mg three times weekly for 4 weeks improved small fiber neuropathy symptoms versus placebo in sarcoidosis patients.
The Science
Stacking & Combinations
Frequently Asked Questions