Sermorelin Dosing: 200-300mcg/Day Protocol (2026)

Sermorelin is a synthetic version of the first 29 amino acids of human growth hormone-releasing hormone (GHRH). It was formerly FDA-approved for GH deficiency diagnosis, giving it a unique history of clinical safety data compared to most research peptides.

Research-context information only. Sermorelin is the active ingredient in FDA-approved products for pediatric growth hormone deficiency; current research-peptide and compounded forms are not FDA-approved and are sold for research purposes only. Protocols, doses, and reactions reported below come from clinical trials and community sources. This article reports what has been documented, not what should be done. Consult a licensed physician for personal medical decisions.

Sermorelin was withdrawn from the market for commercial reasons, not safety concerns. It is currently available only as a research chemical. This is not medical advice.

Sermorelin Dosing Table

Match your vial size below — reconstitution and dose math update automatically.

200 mcg

8 units

0.08 mL

Daily PM SubQ (5-on/2-off)Standard

300 mcg

12 units

0.12 mL

Daily PM SubQ (5-on/2-off)

500 mcg

20 units

0.2 mL

Daily PM SubQAdvanced

Math assumes U-100 insulin syringes (1 mL = 100 units). Verify your syringe matches before injecting. Round half-units to the nearest visible mark.

4 units

0.04 mL

6 units

0.06 mL

10 units

0.1 mL

Daily PM SubQ

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Quick Reference: Standard Protocol

Vial

2 mg

BAC Water

2 mL

Concentration

1,000 mcg/mL

Dose

200-300 mcg (20-30 units on insulin syringe)

Route

Subcutaneous

Timing

Before bed, empty stomach

Frequency

5 days on, 2 days off

Cycle

8 weeks on, 8 weeks off

Storage

Refrigerate, use within 14-28 days

Key detail: Bedtime dosing aligns with natural GH release during deep sleep. Protocols describe an empty stomach — at least 2-3 hours after eating, with food avoided for 1 hour post-injection.

Cycling Details

Community protocols describe starting at 200 mcg daily for weeks 1-2 to assess tolerance, then increasing to 250-300 mcg where response warrants. The 5-on/2-off schedule is the most common community pattern; the 2-day break is described in terms of cost and IGF-1 normalization rather than as a proven requirement.

Sermorelin's short half-life (8-12 minutes) mimics natural GHRH pulses, preserving pulsatile GH patterns rather than creating sustained elevation. This is actually beneficial — it means normal feedback mechanisms remain intact.

Standard cycle is 8 weeks on, 8 weeks off. Some extend to 12-16 weeks with periodic breaks. Competition prep protocols may run 12-16 weeks leading up to an event.

Continuous use versus cycling: what the trials documented

The community 8-on/8-off pattern is one approach; the longest controlled trial describes another. In a 16-week study of nightly GHRH-(1-29) dosing in older adults, nocturnal growth-hormone output stayed elevated across the full treatment period and IGF-1 rose and remained above baseline, with no sign of the pituitary becoming desensitized to nightly stimulation over those 16 weeks (Khorram et al., 1997). That trial did not run past 16 weeks, so it documents sustained response across that window rather than open-ended continuous use.

Community sources therefore describe two paths. Cycled use (commonly 8 weeks on, 8 weeks off) is typically framed around cost and letting IGF-1 normalize between blocks. Continuous nightly use is supported, over the studied window, by the trial record showing maintained GH output without desensitization. Sermorelin's short half-life means each nightly dose is a single transient pulse that clears before the next, which is the mechanism most often cited for why the natural pulsatile pattern is preserved on daily dosing.

Routes of Administration

Subcutaneous injection is the standard route. Protocols describe injecting before bed at the same time nightly for consistency. Abdomen, thigh — standard SC sites. Volume is 0.2-0.3 mL with insulin syringe (29-31 gauge).

Intramuscular is an alternative but less common — no significant difference in effectiveness vs. SC.

Not oral — Sermorelin is a peptide destroyed by stomach acid (unlike MK-677, which is orally bioavailable).

Reconstitution Quick Reference

25 units

30 units

5 mg

2,500 mcg/mL

Math: 2 mg / 2 mL = 1,000 mcg/mL. For 200 mcg: 200 / 1,000 = 0.2 mL = 20 units.

Community protocols describe gentle swirling — not shaking — to avoid degradation, with refrigeration immediately and use within 14-28 days (more fragile than some peptides). Protocols describe protecting from light; powder can be stored at -20 C before reconstitution.

Prefer the prescribed route? Sermorelin is one of the few peptides legitimately compounded under 503A — clinician oversight, intake labs, and shipping in all 50 states.