Source comparison
9. Hormonal selectivity vs sermorelin and GHRP-6
Sermorelin: GHRH(1-29), the unmodified native fragment. Half-life 10-20 minutes. No DAC variant. Largely superseded by CJC-1295 no-DAC in research use because the four CJC substitutions produce longer half-life and greater receptor affinity without loss of sel
This comparison does not assign a generated winner or score.
- Sermorelin: GHRH(1-29), the unmodified native fragment. Half-life 10-20 minutes. No DAC variant. Largely superseded by CJC-1295 no-DAC in research use because the four CJC substitutions produce longer half-life and greater receptor affinity without loss of selectivity.
- GHRP-6: First-generation ghrelin-receptor agonist. Potent GH releaser but also potent orexigen (strong appetite stimulation), moderate cortisol and prolactin elevation. Suitable for appetite research but inferior to ipamorelin for clean growth-hormone secretagogue studies.
- GHRP-2: Intermediate selectivity — better than GHRP-6 but less selective than ipamorelin.
- Hexarelin: Most potent ghrelin-receptor agonist but greatest cortisol and prolactin cross-reactivity. Declining use in contemporary research.
- MK-677 (ibutamoren): Orally bioavailable non-peptide ghrelin-receptor agonist. Useful where oral administration is required; produces greater tonic activation than injectable ghrelin-mimetics. Covered in detail in a separate reference article.