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AOD-9604 vs. Ipamorelin | Comprehensive Comparison

Ipamorelin works by upregulating the production of growth hormone while AOD-9604 mimics some of hGH’s effects. Thus, the two compounds have varying mechanisms and effects. In terms of their respective mechanisms: Ipamorelin stimulates the GHS-R1a in the pituit

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  • Ipamorelin works by upregulating the production of growth hormone while AOD-9604 mimics some of hGH’s effects. Thus, the two compounds have varying mechanisms and effects.
  • In terms of their respective mechanisms:
  • Ipamorelin stimulates the GHS-R1a in the pituitary and causes an increase in hGH levels within 40 minutes when applied to healthy adults. The peptide has a half-life of two hours, and its effects on hGH synthesis last up to three hours. Doses higher than 60mcg/kg of body weight can lead to hGH peaks reaching up to 26.6ng/ml (80mIU/l) [17].
  • In comparison, AOD-9604 does not influence hGH or IGF-1 synthesis in the body. Instead, it appears to increase lipolysis in the body via mechanisms that are not fully elucidated. Preliminary research suggests that these mechanisms may be similar to those observed with exogenous hGH therapy, including the activation of the adrenergic receptors and increased lipolysis in adipocytes [5].
  • In terms of respective effects:
  • Ipamorelin therapy increases serum GH, appetite, and body weight. Preclinical studies of ipamorelin report significant appetite increase and weight increase related to muscle and fat gain. Some animal experiments also showcase a 54% increase in IGF-I and reduced loss of muscle strength loss in drug-induced catabolic conditions [18, 19].
  • In comparison, AOD-9604 appears to result in weight loss, primarily related to fat loss. It has demonstrated significant weight loss in test animals. In one experiment, obese Zucker rats lost around 50% of their weight in 19 days, with the researchers noting 23% increased lipolytic activity, measured as glycerol release from the fatty tissue of the treated animals [20].
  • In brief, it appears that ipamorelin can cause weight and muscle gain, while AOD-9604 may be a weight loss agent.