Source comparison
Athletes MK-677 Protocol Comparison: Dosing Strategies
Conservative Start 12.5mg daily Pre-sleep, empty stomach 8 weeks on, 4 off Improved sleep quality, minimal side effects +3–5 mg/dL fasting glucose Best for athletes new to GH secretagogues or those with insulin sensitivity concerns. Establishes individual resp
This comparison does not assign a generated winner or score.
- Conservative Start
- 12.5mg daily
- Pre-sleep, empty stomach
- 8 weeks on, 4 off
- Improved sleep quality, minimal side effects
- +3–5 mg/dL fasting glucose
- Best for athletes new to GH secretagogues or those with insulin sensitivity concerns. Establishes individual response before escalating
- Standard Athletic
- 25mg daily
- 60–90 min pre-sleep
- 10 weeks on, 4 off
- Maximal GH pulse amplitude, significant recovery enhancement
- +7–10 mg/dL fasting glucose
- Gold standard for athletes seeking measurable body composition and recovery improvements. Requires glucose monitoring
- Every-Other-Day
- 25mg EOD
- Pre-sleep on dosing days
- 16 weeks on, 4 off
- Extended cycle without receptor desensitization
- +4–6 mg/dL fasting glucose
- Emerging protocol showing promise for maintaining benefits while reducing cumulative ghrelin receptor exposure
- High-Response
- 15mg daily
- 12 weeks on, 6 off
- Balanced GH response with minimal glucose disruption
- +5–7 mg/dL fasting glucose
- Ideal for athletes who respond strongly at lower doses. Avoids unnecessary metabolic stress