Source comparison
Best MK-677 Dosage for Muscle Growth: Full Protocol Comparison
10mg daily 30–45% above baseline 1–2kg Minimal (<1kg) None detected Mild increase Subtherapeutic for significant hypertrophy. Useful only for tolerance testing or geriatric populations where metabolic sensitivity is a concern 15mg daily 50–65% above baseline 2
This comparison does not assign a generated winner or score.
- 10mg daily
- 30–45% above baseline
- 1–2kg
- Minimal (<1kg)
- None detected
- Mild increase
- Subtherapeutic for significant hypertrophy. Useful only for tolerance testing or geriatric populations where metabolic sensitivity is a concern
- 15mg daily
- 50–65% above baseline
- 2–3kg
- Moderate (1–1.5kg weeks 2–4)
- Negligible
- Moderate increase
- Lower threshold for meaningful anabolic effect. Appropriate for first-time protocols or subjects with metabolic concerns
- 20mg daily
- 60–90% above baseline
- 3–5kg
- Moderate to high (1.5–2kg weeks 2–4)
- Mild (10–15% HOMA-IR increase)
- Significant increase
- Optimal dose for most research applications. Maximizes IGF-1 response while keeping side effects manageable
- 25mg daily
- 80–100% above baseline
- 3.5–5.5kg
- High (2–3kg weeks 2–4)
- Moderate (15–20% HOMA-IR increase)
- Very significant increase
- Ceiling dose. Marginal additional benefit over 20mg with disproportionate side effect escalation
- 30mg+ daily
- 90–110% above baseline
- 4–6kg (limited data)
- Very high (3+kg weeks 2–4)
- Moderate to high (20+% HOMA-IR increase)
- Extreme increase
- Exceeds therapeutic window. Side effects compound faster than anabolic gains