Source comparison
Best MK-677 Dosage Recovery 2026: Protocol Comparison
Conservative Recovery 12.5mg daily 60–90 min pre-sleep 8 weeks on, 4 weeks off Athletes >40, prediabetic markers, first-time users Low (fasting glucose increase typically <5 mg/dL) Moderate. Measurable soft tissue repair, reduced soreness, improved sleep archi
This comparison does not assign a generated winner or score.
- Conservative Recovery
- 12.5mg daily
- 60–90 min pre-sleep
- 8 weeks on, 4 weeks off
- Athletes >40, prediabetic markers, first-time users
- Low (fasting glucose increase typically <5 mg/dL)
- Moderate. Measurable soft tissue repair, reduced soreness, improved sleep architecture
- Standard Recovery
- 25mg daily
- 10 weeks on, 4 weeks off
- Lean athletes <35, normal glucose tolerance, injury recovery focus
- Moderate (10–15% of users see fasting glucose >105 mg/dL by week 6)
- High. Accelerated healing, reduced inflammatory markers (CRP, IL-6), enhanced nitrogen retention
- Split-Dose (NOT RECOMMENDED)
- 12.5mg AM + 12.5mg PM
- Morning + evening
- 8–12 weeks
- Individuals seeking stable IGF-1 without GH pulse optimisation
- Moderate
- Low. Dilutes nocturnal GH peak, minimal recovery advantage over single nocturnal dose
- Aggressive Recovery
- 25mg daily + 500mg berberine TID
- 12 weeks on, 6 weeks off
- Competitive athletes with injury, monitored glucose, no diabetes history
- Moderate-High (requires weekly glucose monitoring)
- Very High. Maximal IGF-1 elevation, fastest soft tissue healing, but requires metabolic oversight