Source comparison
Best MK-677 Dosage Sleep Quality 2026: Protocol Comparison
5–10mg 60 min pre-bed 8–12% vs baseline 5–8 minutes Minimal. Occasional mild hunger upon waking Subtherapeutic for most adults; may benefit younger individuals with intact GH pulsatility 10–15mg 60–90 min pre-bed 15–22% vs baseline 10–15 minutes Mild transient
This comparison does not assign a generated winner or score.
- 5–10mg
- 60 min pre-bed
- 8–12% vs baseline
- 5–8 minutes
- Minimal. Occasional mild hunger upon waking
- Subtherapeutic for most adults; may benefit younger individuals with intact GH pulsatility
- 10–15mg
- 60–90 min pre-bed
- 15–22% vs baseline
- 10–15 minutes
- Mild transient water retention (1–2 lbs); rare next-day grogginess
- Optimal starting range for sleep improvement. Titrate within this window based on response
- 20–25mg
- 20–27% vs baseline
- 12–18 minutes
- Moderate water retention (2–4 lbs); increased fasting glucose 5–10 mg/dL; mild morning lethargy
- Upper therapeutic range. Reserve for older adults or those with blunted GH response
- 30mg+
- Any timing
- 18–25% vs baseline
- Significant water retention (4–7 lbs); HPA axis activation; sleep fragmentation 4–6 AM; next-day fatigue
- Exceeds sleep benefit threshold. Side effects outweigh marginal architectural gains