Skip to content
Recovery & Performance PeptidesRecovery research and practical context
Source comparison

Best Peptides to Gain Lean Muscle Mass Ranked: Clinical Comparison

The following table ranks peptides by lean mass efficacy based on published trial data, receptor selectivity, and practical considerations including dosing convenience and desensitisation risk. | Peptide | Mechanism | Mean Lean Mass Gain (12 weeks) | Receptor

This comparison does not assign a generated winner or score.

  • The following table ranks peptides by lean mass efficacy based on published trial data, receptor selectivity, and practical considerations including dosing convenience and desensitisation risk.
  • | Peptide | Mechanism | Mean Lean Mass Gain (12 weeks) | Receptor Selectivity | Dosing Frequency | Desensitization Risk | Bottom Line ||—|—|—|—|—|—|| CJC-1295 (non-DAC) + Ipamorelin | GHRH analog + ghrelin agonist | 3.5–4.1% | High (no cortisol/prolactin elevation) | Twice daily (subcutaneous) | Low with cycling | Best synergistic combination for preserving pulsatile GH release || Ipamorelin | Selective ghrelin receptor agonist | 2.8–3.2% | Very high (GHS-R1a specific) | Twice daily (subcutaneous) | Very low | Most selective GHRP. Minimal side effect profile || Hexarelin | Non-selective ghrelin agonist | 3.0–3.6% | Moderate (activates cortisol pathways) | Once daily (requires cycling) | High after 14 days | Highest GH peaks but requires strict cycling || MK-677 (Ibutamoren) | Oral ghrelin agonist | 2.5–3.0% | Moderate (increases insulin/glucose) | Once daily (oral) | Moderate (metabolic adaptation) | Convenient oral option but monitor fasting glucose || GHRP-2 | Non-selective ghrelin a