Source comparison
Best PT-141 Dosage Sexual Dysfunction 2026: Protocol Comparison
On-Demand 1.75–2.0mg SC 45–60 min pre-activity As needed (max 1x/24h) Episodic HSDD, situational arousal deficit 70–80% Nausea (40%), flushing (30%), transient hypertension Chronic Maintenance 1.0–1.5mg SC Independent of activity 2–3x weekly Pervasive low desi
This comparison does not assign a generated winner or score.
- On-Demand
- 1.75–2.0mg SC
- 45–60 min pre-activity
- As needed (max 1x/24h)
- Episodic HSDD, situational arousal deficit
- 70–80%
- Nausea (40%), flushing (30%), transient hypertension
- Chronic Maintenance
- 1.0–1.5mg SC
- Independent of activity
- 2–3x weekly
- Pervasive low desire, chronic HSDD
- 60–70%
- Injection site reactions, cumulative melanocortin exposure
- Dose Escalation
- Start 1.0mg → titrate to 1.75mg over 3 doses
- As needed
- First-time users, nausea-prone patients
- 65–75%
- Reduced nausea vs starting at 1.75mg
- Low-Dose Exploratory
- 0.5–1.0mg SC
- 60 min pre-activity
- Sensitivity testing, elderly patients
- 40–50%
- Minimal, but subtherapeutic efficacy
- Bottom Line
- 1.75mg on-demand
- 45–60 min window
- Highest evidence base
- 78% in Phase 2b trials
- Manageable with pre-dosing anti-nausea