Source comparison
Best Sermorelin Dosage for Body Composition: Peptide Comparison
Sermorelin Acetate GHRH agonist. Amplifies natural GH pulses 200–300 mcg subcutaneous 30 min before sleep 8–12 min plasma; effect lasts 2–4 hours Best for preserving natural GH rhythm; no receptor desensitization at standard doses; requires nightly dosing CJC-
This comparison does not assign a generated winner or score.
- Sermorelin Acetate
- GHRH agonist. Amplifies natural GH pulses
- 200–300 mcg subcutaneous
- 30 min before sleep
- 8–12 min plasma; effect lasts 2–4 hours
- Best for preserving natural GH rhythm; no receptor desensitization at standard doses; requires nightly dosing
- CJC-1295 (DAC)
- Modified GHRH. Extended half-life
- 1–2 mg subcutaneous
- Once weekly
- 6–8 days
- Sustained IGF-1 elevation; higher risk of chronic GH receptor activation and blunted endogenous pulses
- Ipamorelin
- Ghrelin mimetic. Stimulates GH release via different pathway
- Pre-workout or before sleep
- 2 hours
- Often stacked with sermorelin for synergistic effect; minimal effect on cortisol or prolactin
- MK-677 (Ibutamoren)
- Oral ghrelin receptor agonist
- 10–25 mg oral
- Once daily, any time
- 24 hours
- Convenient oral dosing; increases appetite significantly; chronic elevation may reduce natural GH pulsatility
- Tesamorelin
- GHRH analog. FDA-approved for lipodystrophy
- 2 mg subcutaneous
- Daily, before sleep
- 26–38 min
- Strongest evidence for visceral fat reduction; prescription-only in most jurisdictions