Source comparison
Best SS-31 Dosage: Research Model Comparison
Cardiac ischemia-reperfusion models 1–3mg/kg Once daily or 30min pre-event 24–72 hours (infarct size reduction) Best evidence base. Multiple RCTs show cardiolipin stabilization prevents reperfusion injury more effectively than antioxidants Neurodegenerative di
This comparison does not assign a generated winner or score.
- Cardiac ischemia-reperfusion models
- 1–3mg/kg
- Once daily or 30min pre-event
- 24–72 hours (infarct size reduction)
- Best evidence base. Multiple RCTs show cardiolipin stabilization prevents reperfusion injury more effectively than antioxidants
- Neurodegenerative disease models
- 3–5mg/kg
- Twice daily
- 4–8 weeks (oxidative marker reduction)
- Requires sustained dosing due to BBB kinetics. Single doses show minimal CNS penetration
- Metabolic syndrome / aging research
- 0.25–2mg/kg
- Once daily
- 2–4 weeks (mitochondrial respiration improvement)
- Start low and titrate. If no response at 1mg/kg after 2 weeks, higher doses unlikely to help
- Acute mitochondrial toxicity models
- 5mg/kg
- Single dose or twice daily × 3 days
- 6–24 hours (ATP preservation)
- High doses justified only when mitochondrial damage is severe and time-limited
- Skeletal muscle fatigue studies
- 0.5–1mg/kg
- 60–90min pre-exercise
- Single session (contractile endurance)
- Lower doses sufficient due to skeletal muscle's high perfusion. Effect wears off within 12 hours