Source comparison
Best Tesamorelin Dosage for Body Composition: Comparison
2mg SC daily (fasted, pre-bed) 15–18% +1–2% 8–12 Phase 3 RCTs (n>800) Gold standard. Only protocol with reproducible VAT reduction without lean mass loss 1mg SC daily 5–7% No significant change 4–6 Observational studies Below threshold for meaningful lipolysis
This comparison does not assign a generated winner or score.
- 2mg SC daily (fasted, pre-bed)
- 15–18%
- +1–2%
- 8–12
- Phase 3 RCTs (n>800)
- Gold standard. Only protocol with reproducible VAT reduction without lean mass loss
- 1mg SC daily
- 5–7%
- No significant change
- 4–6
- Observational studies
- Below threshold for meaningful lipolysis. Wastes time without cost savings
- 2mg SC 3x/week
- 8–10%
- 8–12 (on injection days)
- Small pilot studies
- Inconsistent GH pulsing. Misses the circadian alignment that drives VAT selectivity
- 3–4mg SC daily
- 16–20%
- 12–18
- Phase 2 dose-finding trials
- No additional benefit over 2mg. Higher adverse event rate (arthralgia, oedema)
- Exogenous rhGH 2 IU daily
- 10–15%
- +3–5%
- 15–25 (sustained 6–8 hrs)
- Multiple RCTs
- Suppresses endogenous GH axis, insulin resistance risk, regulatory/cost constraints