Source comparison
Best Tesamorelin + Ipamorelin Blend Dosage Anti-Aging 2026: Protocol Comparison
Before selecting a dosing protocol, understand that anti-aging efficacy is tied to sustained IGF-1 elevation and VAT reduction. Not milligram totals. The table below compares three evidence-based protocols used in clinical and research settings as of 2026. Con
This comparison does not assign a generated winner or score.
- Before selecting a dosing protocol, understand that anti-aging efficacy is tied to sustained IGF-1 elevation and VAT reduction. Not milligram totals. The table below compares three evidence-based protocols used in clinical and research settings as of 2026.
- Conservative (Lipodystrophy-Derived)
- 1mg daily
- 200mcg daily
- 30–60 min before sleep
- 30–40% above baseline
- Low. Sustainable long-term with 5-on/2-off cycling
- This is the gold standard protocol validated in FDA trials for Egrifta; prioritise this if biomarker tracking and VAT reduction are primary goals
- Moderate (Enhanced GH Pulse)
- 1.5mg daily
- 250mcg daily
- 45 min before sleep
- 40–50% above baseline
- Moderate. Requires 5-on/2-off cycling after week 12
- Higher IGF-1 ceiling but requires closer glucose monitoring; suitable for individuals with confirmed low baseline IGF-1 (<100 ng/mL)
- Aggressive (Short-Duration)
- 2mg daily
- 300mcg daily
- 60 min before sleep
- 50–60% above baseline (weeks 1–8 only)
- High. Plateau or reversal likely by week 10 without dose breaks
- Not recommended for sustained anti-aging use; appropriate only for 8–12 week cycles with mandatory 4-week washout between cycles