Source comparison
BPC-157 Chronic Fatigue Research Mechanism: Protocol Comparison
Chronic restraint stress (mouse) 10 mcg/kg Intraperitoneal 14 days ATP synthesis capacity in skeletal muscle +34% restoration vs untreated Demonstrates mitochondrial mechanism; short duration limits long-term inference Chronic unpredictable mild stress (rat) S
This comparison does not assign a generated winner or score.
- Chronic restraint stress (mouse)
- 10 mcg/kg
- Intraperitoneal
- 14 days
- ATP synthesis capacity in skeletal muscle
- +34% restoration vs untreated
- Demonstrates mitochondrial mechanism; short duration limits long-term inference
- Chronic unpredictable mild stress (rat)
- Subcutaneous
- 21 days
- Serum IL-6 and TNF-α levels
- −38% IL-6, −42% TNF-α
- Strong anti-inflammatory effect; behavioral improvements align with cytokine reduction
- Experimentally induced colitis (rat)
- 10 days
- Intestinal permeability (FITC-dextran) and treadmill endurance
- −46% permeability, +28% endurance time
- Gut-brain axis mechanism validated; systemic fatigue improved via barrier repair
- Post-ischemic injury (rat)
- 10–20 mcg/kg
- Capillary density in affected tissue
- +52% vascular density at 20 mcg/kg
- Dose-dependent angiogenesis; higher doses required for vascular repair vs inflammation