Source comparison
BPC-157 Concussion Recovery Mechanism: Study Comparison
Rodent cortical impact (Zagreb, 2018) 10 mcg/kg SC 30 min post-injury GABAergic receptor upregulation 42% increase in GABA receptor density at 24h Limited. Human dosing unknown Rat fluid percussion injury (2020) 10 mg/kg IP Immediate post-injury iNOS suppressi
This comparison does not assign a generated winner or score.
- Rodent cortical impact (Zagreb, 2018)
- 10 mcg/kg SC
- 30 min post-injury
- GABAergic receptor upregulation
- 42% increase in GABA receptor density at 24h
- Limited. Human dosing unknown
- Rat fluid percussion injury (2020)
- 10 mg/kg IP
- Immediate post-injury
- iNOS suppression, eNOS preservation
- 58% reduction in iNOS expression
- Moderate. IP route not clinically viable
- Mouse closed-head injury (2021)
- 1 hour post-injury
- Blood-brain barrier stabilization
- 71% reduction in BBB permeability (Evans blue)
- Low. Mouse injury model, no human validation
- Rat cortical lesion (2019)
- 1 mg/kg SC
- Immediate + daily × 7 days
- Dopaminergic pathway modulation
- Improved motor recovery scores at 14 days
- Minimal. Chronic dosing protocol, not acute neuroprotection