Source comparison
BPC-157 for Achilles Tendinitis Research: Study Design Comparison
Krivic et al. (2006) J Physiol Pharmacol Rat Achilles transection 10 µg/kg IP daily × 14 days Tensile strength recovery 60% increase in load-to-failure at day 14 First demonstration of dose-dependent effect; limited by short follow-up and lack of biomechanical
This comparison does not assign a generated winner or score.
- Krivic et al. (2006) J Physiol Pharmacol
- Rat Achilles transection
- 10 µg/kg IP daily × 14 days
- Tensile strength recovery
- 60% increase in load-to-failure at day 14
- First demonstration of dose-dependent effect; limited by short follow-up and lack of biomechanical testing beyond 2 weeks
- Cerovecki et al. (2010) J Orthop Res
- Rat Achilles transection + corticosteroid
- 10 µg/kg IP or local injection
- Collagen organization score
- Reversed corticosteroid-induced healing impairment
- Clinically relevant because corticosteroids are commonly used in tendinopathy; suggests BPC-157 may counteract anti-angiogenic effects
- Staresinic et al. (2006) J Physiol Paris
- 10 µg/kg to 10 mg/kg IP
- Histological healing grade
- Dose-response observed; maximal effect at 10 µg/kg
- Higher doses didn't improve outcomes, suggesting therapeutic ceiling; raises questions about human dose extrapolation
- Tkalcevic et al. (2007) Regul Pept
- Rat Achilles transection + NSAIDs
- 10 µg/kg IP daily
- Tendon functional recovery
- Improved healing despite NSAID co-administration
- Relevant for athletes using NSAIDs; BPC-157 didn't negate NSAID effects but maintained healing support