Source comparison
BPC-157 for Calf Strain Research: Study Comparison
Rat gastrocnemius transection (2014) 10 mcg/kg IP daily × 14 days Muscle healing score improved 67% vs control Complete regeneration at 28 days vs persistent fibrosis in controls Histology showed organised myofibril structure, minimal scar tissue Most cited pr
This comparison does not assign a generated winner or score.
- Rat gastrocnemius transection (2014)
- 10 mcg/kg IP daily × 14 days
- Muscle healing score improved 67% vs control
- Complete regeneration at 28 days vs persistent fibrosis in controls
- Histology showed organised myofibril structure, minimal scar tissue
- Most cited protocol. Established baseline for dosing and timeline expectations
- Rat Achilles tendon rupture (2016)
- 10 mcg/kg SC daily × 21 days
- Tensile strength 78% of pre-injury at day 21
- Functional weight-bearing restored at day 10 vs day 18 in controls
- Collagen fibre alignment score 35% higher than control group
- Demonstrated mechanism applies across tendon and muscle tissue types
- Rat gastrocnemius crush injury (2018)
- 500 mcg/kg IM every 48 hours × 14 days
- 82% tensile strength recovery vs 54% control
- Inflammation resolution 40% faster than untreated
- FAK-paxillin pathway activation confirmed via immunohistochemistry
- Higher intermittent dosing produced comparable outcomes to daily low-dose. Suggests threshold effect
- Rabbit quadriceps strain (2020)
- 250 mcg/kg SC daily × 10 days
- VEGF expression 3.2× baseline at injury site
- Return to normal gait mechanics at day 12 vs day 19
- Capillary density increased 58% vs control tissue
- Larger animal model validates mechanism seen in rodents. Dose scaling remains unclear