Source comparison
BPC-157 for Herniated Disc Research: Comparison of Study Models
Rat (2023, J Orthop Res) Surgical annular puncture 10 µg/kg daily IP × 28 days 34% increase in proteoglycan content; preserved disc height vs controls Strongest evidence for structural preservation. IP dosing shows systemic distribution Rabbit (2022, Biomedici
This comparison does not assign a generated winner or score.
- Rat (2023, J Orthop Res)
- Surgical annular puncture
- 10 µg/kg daily IP × 28 days
- 34% increase in proteoglycan content; preserved disc height vs controls
- Strongest evidence for structural preservation. IP dosing shows systemic distribution
- Rabbit (2022, Biomedicine)
- Chondroitinase ABC injection
- 50 µg/kg daily local × 21 days
- 47% reduction in inflammatory markers; improved MRI signal intensity
- Local administration may enhance tissue-specific effects but complicates human translation
- Rat (2021, Regul Pept)
- Needle puncture degeneration
- 10 µg/kg daily IP × 14 days
- 58% increased microvascular density in endplate tissue
- Angiogenic mechanism confirmed. Vascular restoration is dose-dependent
- Mouse (2020, Eur J Pharmacol)
- Tail compression model
- 100 µg/kg daily SC × 10 days
- Reduced apoptosis in nucleus pulposus cells by 39%
- Anti-apoptotic effect suggests cell survival benefit beyond structural repair