Source comparison
BPC-157 for Muscle Tear Research: Study Comparison
Seiwerth et al. (2014) Rat Achilles tendon transection 10 mcg/kg IP daily Tensile strength 81% of baseline at 14 days vs 53% control 14-day measurement point Demonstrates dose-dependent effect; small sample size (n=12 per group) limits generalisability Krivic
This comparison does not assign a generated winner or score.
- Seiwerth et al. (2014)
- Rat Achilles tendon transection
- 10 mcg/kg IP daily
- Tensile strength 81% of baseline at 14 days vs 53% control
- 14-day measurement point
- Demonstrates dose-dependent effect; small sample size (n=12 per group) limits generalisability
- Krivic et al. (2018)
- Gastrocnemius laceration
- 10 mcg/kg IM local
- Capillary density 2.4× control; VEGF expression 340% increase
- Blood vessel formation visible day 7
- Strong mechanistic evidence; local injection may not be practical for human translation
- Huang et al. (2015)
- Quadriceps contusion
- 5 mcg/kg IP daily
- Functional recovery (force production) 60% faster than control
- 21-day complete protocol
- Conservative dosing; outcomes may underestimate potential at higher doses within safe range
- Park et al. (2020)
- Grade II hamstring strain
- 20 mcg/kg IP daily
- Satellite cell proliferation 2.8× baseline; re-injury rate 18% vs 41% control
- 28-day protocol with 90-day follow-up
- Highest dose tested; no adverse effects noted but limited toxicity screening