Source comparison
BPC-157 for TBI Research: Model Comparison
Lateral Fluid Percussion (Rats) 10 mcg/kg IP daily × 7 days Lesion volume reduction 42% smaller lesion, p<0.01 Single-center study, n=40 Weight-Drop TBI (Mice) 5 mcg/kg IP single dose Blood-brain barrier integrity (Evans blue) 38% reduction in extravasation at
This comparison does not assign a generated winner or score.
- Lateral Fluid Percussion (Rats)
- 10 mcg/kg IP daily × 7 days
- Lesion volume reduction
- 42% smaller lesion, p<0.01
- Single-center study, n=40
- Weight-Drop TBI (Mice)
- 5 mcg/kg IP single dose
- Blood-brain barrier integrity (Evans blue)
- 38% reduction in extravasation at 24h
- No long-term functional follow-up
- Cortical Impact Injury (Rats)
- 10 mcg/kg IP immediately post-injury
- Neurological severity score (NSS)
- Improved from 12.3 to 7.8 at day 7
- No blinding of outcome assessors
- Closed-Head Injury (Mice)
- 10 mcg/kg IP daily × 14 days
- Seizure incidence at 30 days
- 60% lower spontaneous seizure rate
- Seizure detection method not validated