Source comparison
BPC-157 Pharmacology Studies: Comparison Across Research Models
Achilles tendon transection (rat) Tensile strength restoration at 14 days 78% vs 31% VEGF/FGF upregulation, collagen organization 10 mcg/kg daily Strongest evidence for tendon healing acceleration Ethanol-induced gastric ulcer (rat) Lesion area reduction 60–80
This comparison does not assign a generated winner or score.
- Achilles tendon transection (rat)
- Tensile strength restoration at 14 days
- 78% vs 31%
- VEGF/FGF upregulation, collagen organization
- 10 mcg/kg daily
- Strongest evidence for tendon healing acceleration
- Ethanol-induced gastric ulcer (rat)
- Lesion area reduction
- 60–80% reduction
- Increased mucosal blood flow, HSP70 upregulation
- 10–100 mcg/kg
- Consistent cytoprotective effect across ulcer models
- Ischemia-reperfusion injury (rat femoral artery ligation)
- Blood flow restoration to ischemic limb
- 40–55% improvement
- Angiogenesis via VEGFR-2, NO modulation
- Evidence for collateral vessel formation
- IBD analog (TNBS-induced colitis, rat)
- Histological damage score, inflammatory markers
- 50–65% reduction in damage score
- TNF-α and IL-6 downregulation, mucosal barrier stabilization
- Promising for gut barrier integrity studies
- Myocardial injury (isoproterenol-induced, rat)
- Infarct size, ejection fraction
- 30–40% infarct size reduction
- Cardioprotective via anti-apoptotic signaling, preserved mitochondrial function
- 10 mcg/kg pre-treatment
- Limited studies; mechanism less defined than musculoskeletal effects