Source comparison
BPC-157 Research Tendon Considerations: Study Comparison
Rat Achilles Transection (2016) Intraperitoneal 10 mcg/kg daily Tensile strength at 14 days 47% increase vs control Strong model for acute injury; IP route provides systemic effect but lower local concentration Rat Patellar Tendon Defect (2018) Intramuscular (
This comparison does not assign a generated winner or score.
- Rat Achilles Transection (2016)
- Intraperitoneal
- 10 mcg/kg daily
- Tensile strength at 14 days
- 47% increase vs control
- Strong model for acute injury; IP route provides systemic effect but lower local concentration
- Rat Patellar Tendon Defect (2018)
- Intramuscular (local)
- 20 mcg/kg twice daily
- Collagen fiber density
- Significantly higher Type I collagen deposition
- Local IM delivery may optimize bioavailability at injury site; dose 2× higher than IP studies
- Rat Rotator Cuff Tear (2020)
- Subcutaneous
- 15 mcg/kg daily
- VEGF expression and capillary count
- 3.2× higher capillary density at day 7
- Subcutaneous route replicates practical human use; vascular growth effect clearly demonstrated
- Rabbit Flexor Tendon Repair (2019)
- Intra-tendon injection
- 50 mcg total dose
- Adhesion formation and gliding function
- Reduced adhesions without strength compromise
- Intra-tendon route not practical for most human tendons; adhesion reduction clinically meaningful