Source comparison
BPC-157 Studied Achilles Tendonitis: Comparison Table
Rat Achilles Transection (Zagreb 2011) Full-thickness tendon severance + surgical repair 10 micrograms/kg IP daily × 14 days Biomechanical load-to-failure at day 14 78% intact strength vs 51% control Organized collagen Type I deposition accelerated by 7 days v
This comparison does not assign a generated winner or score.
- Rat Achilles Transection (Zagreb 2011)
- Full-thickness tendon severance + surgical repair
- 10 micrograms/kg IP daily × 14 days
- Biomechanical load-to-failure at day 14
- 78% intact strength vs 51% control
- Organized collagen Type I deposition accelerated by 7 days vs saline
- Rabbit Achilles Tenotomy (Zagreb 2016)
- Partial-thickness longitudinal tear
- 10 micrograms/kg IP daily × 21 days
- Histological fiber organization score
- 4.2/5 vs 2.1/5 control (polarized microscopy)
- Parallel fiber alignment achieved 10 days earlier than untreated
- Rat Collagenase Injection Model (Zagreb 2019)
- Chemical degradation (0.3mg Type I collagenase)
- 5 micrograms/kg peritendinous injection daily × 14 days
- Inflammatory marker expression (IL-6, TNF-alpha)
- 62% reduction IL-6 at 72hr vs control
- Local injection reduced dose requirement by 50% vs systemic delivery
- In Vitro Tendon Fibroblast Culture (Zagreb 2020)
- Isolated human tenocytes exposed to BPC-157
- 0.1–10 micrograms/mL culture medium × 48hr
- Collagen Type I mRNA expression
- 3.2× baseline at 1 microgram/mL
- Direct cell-level collagen synthesis upregulation confirmed without growth factors