Source comparison
BPC-157 Studied Chronic Pain Research: Comparison Across Injury Models
Achilles Tendon Rupture Mechanical nociception from disorganized collagen; substance P release in neovascular tissue 10 mcg/kg daily IP × 14 days Days 3–5 (mechanical threshold improvement) Collagen realignment visible day 10–14; tensile strength 78% of intact
This comparison does not assign a generated winner or score.
- Achilles Tendon Rupture
- Mechanical nociception from disorganized collagen; substance P release in neovascular tissue
- 10 mcg/kg daily IP × 14 days
- Days 3–5 (mechanical threshold improvement)
- Collagen realignment visible day 10–14; tensile strength 78% of intact by day 14
- BPC-157 couples pain reduction with measurable tendon healing. Not symptom masking
- Sciatic Nerve Crush
- Wallerian degeneration; dorsal root ganglion hyperexcitability; central sensitization
- 10 mcg/kg daily IP × 7–14 days
- Days 5–7 (thermal hyperalgesia reduction)
- GAP-43 upregulation by day 7; functional gait recovery by day 14
- Reduces neuropathic pain by accelerating axon regeneration and dampening spinal microglial activation
- Osteoarthritis (MIA model)
- Inflammatory cytokines (IL-1β, TNF-α); subchondral bone nociceptor sensitization
- 10 mcg/kg daily IP × 21 days
- Days 7–10 (weight-bearing improvement)
- Cartilage proteoglycan content stabilized; synovial inflammation reduced by day 21
- Analgesic effect tied to reduced joint inflammation and partial chondroprotection. Not joint regeneration
- Chronic Lateral Epicondylitis (case reports)
- Tendon degeneration; failed healing response; neovascular nerve ingrowth
- 250–500 mcg subcutaneous daily × 4–6 weeks
- Weeks 2–3 (pain on resisted wrist extension improves)
- Ultrasound shows improved tendon echogenicity weeks 4–6
- Case-level evidence suggests pain reduction correlates with tissue remodeling