Source comparison
BPC-157 Studied Concussion Recovery: Model Comparison
Controlled Cortical Impact (Rat) 10 µg/kg IP daily × 7 days Brain edema reduction (MRI volumetry) 42% reduction at 72h University of Zagreb, 2014 Strongest evidence for acute neuroprotection; dosage translates to ~120–160 µg in humans; timing critical (within
This comparison does not assign a generated winner or score.
- Controlled Cortical Impact (Rat)
- 10 µg/kg IP daily × 7 days
- Brain edema reduction (MRI volumetry)
- 42% reduction at 72h
- University of Zagreb, 2014
- Strongest evidence for acute neuroprotection; dosage translates to ~120–160 µg in humans; timing critical (within 6h post-injury)
- Fluid Percussion Injury (Rat)
- 10 µg/kg IP daily × 14 days
- Motor coordination recovery (rotarod test)
- 35% faster recovery to baseline
- J Physiol Pharmacol, 2016
- Motor benefits replicate across models; functional recovery faster than histological repair; suggests symptom management utility even if structural repair incomplete
- Diffuse Axonal Injury (Mouse)
- 5 µg/kg IP daily × 21 days
- GAP-43 expression (immunohistochemistry)
- 71% increase vs control at 14d
- Brain Res Bull, 2017
- Axon regeneration marker; correlates with cognitive recovery but regional specificity (hippocampus > corpus callosum) limits generalizability to all concussion types
- Blood-Brain Barrier Disruption (Rat)
- 10 µg/kg IP single dose + daily × 3d
- Claudin-5 expression, Evans blue extravasation
- 62% increased claudin-5, 54% reduced leakage
- Mol Neurobiol, 2018
- BBB stabilization is mechanistically novel; no FDA-approved therapy targets tight junction proteins; time-window dependency (6h) makes prophylactic use more practical than acute intervention