Source comparison
BPC-157 Studied Fibromyalgia Research — Comparison
Chronic Constriction Injury (sciatic nerve) Mechanical allodynia (paw withdrawal threshold) 10 mcg/kg SC daily 52% reduction in pain behaviour 14 days Most mechanistically relevant to neuropathic pain component in fibromyalgia. Demonstrates nerve regeneration
This comparison does not assign a generated winner or score.
- Chronic Constriction Injury (sciatic nerve)
- Mechanical allodynia (paw withdrawal threshold)
- 10 mcg/kg SC daily
- 52% reduction in pain behaviour
- 14 days
- Most mechanistically relevant to neuropathic pain component in fibromyalgia. Demonstrates nerve regeneration effects
- Complete Freund's Adjuvant (inflammatory pain)
- Thermal hyperalgesia + inflammatory markers
- 10–100 mcg/kg SC daily
- 38–45% reduction in hyperalgesia; 30% reduction in IL-6
- 7–10 days
- Models inflammatory contribution. Cytokine reduction directly addresses elevated markers seen in fibromyalgia CSF
- Reserpine-induced myalgia
- Grip strength, mechanical sensitivity, fatigue markers
- 44% improvement in strength; 35% reduction in allodynia
- 7 days
- Closest phenotype match to fibromyalgia. Systemic monoamine depletion + muscle pain mirrors human presentation
- Chronic Unpredictable Mild Stress
- Depression-like behaviour + pain sensitivity
- 10 mcg/kg IP daily
- Reversal of stress-induced 5-HT1A receptor reduction
- 21 days
- Addresses comorbid depression and stress-amplified pain. Serotonin system modulation overlaps with SNRI mechanism