Source comparison
BPC-157 Studied Intestinal Permeability: Comparison of Research Models
TNBS-Induced Colitis Chemical irritant causing transmural inflammation 10 μg/kg daily for 7–14 days Mucosal ulceration index, inflammatory cytokine levels 60% reduction in ulceration, 70% reduction in TNF-α and IL-6 Most relevant model for Crohn's-like inflamm
This comparison does not assign a generated winner or score.
- TNBS-Induced Colitis
- Chemical irritant causing transmural inflammation
- 10 μg/kg daily for 7–14 days
- Mucosal ulceration index, inflammatory cytokine levels
- 60% reduction in ulceration, 70% reduction in TNF-α and IL-6
- Most relevant model for Crohn's-like inflammatory damage. Demonstrates both structural and biochemical barrier restoration
- NSAID-Induced Enteropathy
- COX enzyme inhibition disrupting prostaglandin synthesis
- 10–100 μg/kg before or after NSAID exposure
- Intestinal lesion counts, mucosal blood flow
- 80% reduction in lesion formation
- Strong evidence for preventive and reparative effects. Particularly relevant for patients on long-term NSAID therapy
- Ischemia-Reperfusion Injury
- Blood flow interruption followed by restoration
- 10 μg/kg administered at reperfusion
- Bacterial translocation to lymph nodes, vascular density
- 65% reduction in bacterial translocation, restored mucosal vascularisation within 72 hours
- Functional barrier measure (bacterial translocation) is the gold standard. Shows BPC-157 improves actual permeability, not just tissue appearance