Source comparison
BPC-157 Studied Rheumatoid Arthritis: Model Comparison
Adjuvant-Induced Arthritis (AIA) T-cell mediated, mimics human RA inflammatory cascade 10 mcg/kg IP daily Joint swelling, histological erosion score, cytokine levels 70% reduction in swelling, 60% reduction in erosion, 50% cytokine suppression Adjuvant model m
This comparison does not assign a generated winner or score.
- Adjuvant-Induced Arthritis (AIA)
- T-cell mediated, mimics human RA inflammatory cascade
- 10 mcg/kg IP daily
- Joint swelling, histological erosion score, cytokine levels
- 70% reduction in swelling, 60% reduction in erosion, 50% cytokine suppression
- Adjuvant model may over-represent innate immunity contribution vs human RA
- Collagen-Induced Arthritis (CIA)
- B-cell and antibody-driven joint attack
- Cartilage degradation markers (MMP-3, aggrecan loss)
- 40% reduction in MMP-3, preserved cartilage thickness on histology
- CIA more accurately models antibody-mediated damage; result suggests BPC-157 protects cartilage matrix
- Delayed Treatment (AIA)
- Established arthritis, started 14 days post-induction
- 10 mcg/kg IP daily for 14 days
- Joint inflammation score, weight-bearing recovery
- 40–50% improvement even after disease onset
- Delayed response suggests tissue repair mechanism, not just prevention