Source comparison
BPC-157 Torn Rotator Cuff Mechanism: Evidence Comparison
Rat Achilles Tendon Transection (2010) 10 µg/kg daily, systemic Tendon-to-bone healing strength 40% faster biomechanical recovery at 14 days VEGF upregulation, increased angiogenesis Rat Rotator Cuff Tear Model (2019) 10 µg/kg daily, local injection Tendon rea
This comparison does not assign a generated winner or score.
- Rat Achilles Tendon Transection (2010)
- 10 µg/kg daily, systemic
- Tendon-to-bone healing strength
- 40% faster biomechanical recovery at 14 days
- VEGF upregulation, increased angiogenesis
- Rat Rotator Cuff Tear Model (2019)
- 10 µg/kg daily, local injection
- Tendon reattachment quality
- 35% higher failure load at 28 days
- Fibroblast proliferation, collagen Type I ratio shift
- In Vitro Human Fibroblast Migration Assay (2017)
- 1–10 ng/mL culture media
- Cell migration velocity
- 2.5× faster migration than untreated cells
- FAK-paxillin pathway activation, integrin expression
- Human Observational Case Series (2022, n=47)
- 250–500 µg daily, subcutaneous
- Self-reported pain and function scores
- Mean 3.2-week reduction in return-to-activity timeline
- Not mechanistically isolated (multi-intervention protocol)
- Bottom Line
- Doses scale from animal studies; human equivalence unclear
- Strongest evidence is preclinical; human data is observational only
- Consistent signal across models for faster healing
- VEGF-mediated angiogenesis and fibroblast activity are central mechanisms