Source comparison
Calculate IGF-1 LR3 Dosage: Species Comparison
The following table presents weight-adjusted dosing ranges used in published IGF-1 LR3 research across species, along with the metabolic rationale and typical reconstitution volumes for each model. The bottom-line assessment reflects Real Peptides' analysis of
This comparison does not assign a generated winner or score.
- The following table presents weight-adjusted dosing ranges used in published IGF-1 LR3 research across species, along with the metabolic rationale and typical reconstitution volumes for each model. The bottom-line assessment reflects Real Peptides' analysis of reproducibility and translational validity based on current literature.
- Mouse (C57BL/6)
- 20–30g
- 40–100 mcg/kg
- 1–3 mcg (0.025kg × 80mcg/kg = 2mcg)
- 1mg in 5mL = 200mcg/mL
- High metabolic rate demands elevated per-kg dosing; excellent reproducibility but translation to primates requires 30–50× dose reduction per kilogram
- Rat (Sprague-Dawley)
- 200–400g
- 20–80 mcg/kg
- 6–24 mcg (0.3kg × 60mcg/kg = 18mcg)
- 1mg in 2mL = 500mcg/mL
- Most extensively published model; dose-response curves well-characterized; injection volumes practical with U-100 syringes
- Rabbit (New Zealand White)
- 3–5kg
- 5–20 mcg/kg
- 20–80 mcg (4kg × 15mcg/kg = 60mcg)
- Intermediate model between rodents and primates; limited IGF-1 LR3 literature but established for native IGF-1 studies; practical for subcutaneous depot studies
- Primate (Macaca fascicularis)
- 4–8kg
- 0.5–2 mcg/kg
- 3–12 mcg (6kg × 1.5mcg/kg = 9mcg)
- Closest metabolic translation to human physiology; requires ultra-low dosing and precise measurement; higher dilution improves volumetric accuracy
- Porcine (Yucatan minipig)
- 30–60kg
- 0.3–1 mcg/kg
- 15–50 mcg (50kg × 0.8mcg/kg = 40mcg)
- Emerging translational model for metabolic and cardiovascular research; body composition closer to human than rodents; limited IGF-1 LR3 precedent requires conservative dose escalation
- When you calculate IGF-1 LR3 dosage for a new species model without published precedent, apply allometric scaling based on the 0.75-power exponent of body mass rather than linear weight adjustment. The formula: Dose_Species2 = Dose_Species1 × (Weight_Species2 ÷ Weight_Species1)^0.75. This accounts for the non-linear relationship between body size and metabolic rate. A 5kg rabbit does not require 25× the dose of a 200g rat (linear scaling) but rather approximately 10× the dose (allometric scaling).