Source comparison
CJC-1295 Animal Research: Species & Outcome Comparison
Sprague-Dawley Rats 10–1000 mcg/kg SC 1.9× at 200 mcg/kg 8–12% at 200–500 mcg/kg Facial flushing, mild hyperglycaemia >500 mcg/kg Established dose-response curve; effects plateau above 200 mcg/kg; rodent model overstates human response magnitude Rhesus Macaque
This comparison does not assign a generated winner or score.
- Sprague-Dawley Rats
- 10–1000 mcg/kg SC
- 1.9× at 200 mcg/kg
- 8–12% at 200–500 mcg/kg
- Facial flushing, mild hyperglycaemia >500 mcg/kg
- Established dose-response curve; effects plateau above 200 mcg/kg; rodent model overstates human response magnitude
- Rhesus Macaques
- 30–300 mcg/kg SC
- 2.8× at 300 mcg/kg
- 4.2% at 300 mcg/kg
- Transient insulin resistance in 2/9 subjects
- Primate data shows steeper IGF-1 response but shorter duration than rodents; more conservative effect size on lean mass
- Domestic Pigs
- 50–200 mcg/kg SC
- 1.6× at 150 mcg/kg
- 3.1% at 150 mcg/kg
- Injection site inflammation in 18% of subjects
- Large animal model; pharmacokinetics closer to humans than rodents; subcutaneous absorption rate variable across sites