Source comparison
CJC-1295 DAC vs no-DAC (Mod GRF 1-29): how do they compare?
The two forms share the same tetrasubstituted GHRH(1–29) core and act on the same receptor. The difference is entirely in duration and, consequently, in the pattern of GH release they produce. The no-DAC form (Mod GRF 1-29) is short-acting, with a reported hal
This comparison does not assign a generated winner or score.
- The two forms share the same tetrasubstituted GHRH(1–29) core and act on the same receptor. The difference is entirely in duration and, consequently, in the pattern of GH release they produce. The no-DAC form (Mod GRF 1-29) is short-acting, with a reported half-life in the range of about 30 minutes — long enough to drive a single, physiologic-looking GH pulse and then clear. The DAC form binds albumin and produces a prolonged, low-level elevation of GH and IGF-1 that the community often calls a “GH bleed,” lasting days rather than minutes.
- Molecular basis
- Tetrasubstituted GRF(1–29) + maleimide/Lys30 albumin-binding appendage
- Tetrasubstituted GRF(1–29) only
- Approximate half-life
- ~6–8 days (albumin-bound)
- ~30 minutes
- GH release pattern
- Sustained, prolonged elevation (“bleed”); blunts natural pulsatility
- Short, discrete pulse that more closely mimics endogenous GHRH
- IGF-1 effect (in research)
- Elevated for many days after a single dose; can accumulate with repeat dosing
- Shorter-lived, pulse-associated changes
- Frequency studied in research settings
- Infrequent administration (e.g., weekly-type intervals in animal work)
- More frequent administration to reproduce repeated pulses
- Published human evidence
- One key single-dose PK/PD study (Teichman 2006) plus a preclinical base
- Very limited; little dedicated published human trial data
- For a deeper, protocol-level breakdown of the two forms and how each is handled in a research context, see the CJC-1295 no-DAC 5 mg research protocol and the companion CJC-1295 DAC 5 mg research protocol. These pages describe reconstitution and handling conventions, not human dosing advice.