Source comparison
CJC-1295 Downstream Effects: Pathway Comparison
IGF-1 Synthesis Hepatic GHR activation → IGF-1 gene transcription 72–96 hours post-dose 10–14 days Liver, then systemic distribution 1.6× baseline IGF-1 at 96h (JCEM study) Lipolysis Adipocyte HSL phosphorylation via GH receptor 6–12 hours post-dose 6–8 days (
This comparison does not assign a generated winner or score.
- IGF-1 Synthesis
- Hepatic GHR activation → IGF-1 gene transcription
- 72–96 hours post-dose
- 10–14 days
- Liver, then systemic distribution
- 1.6× baseline IGF-1 at 96h (JCEM study)
- Lipolysis
- Adipocyte HSL phosphorylation via GH receptor
- 6–12 hours post-dose
- 6–8 days (duration of GH elevation)
- White adipose tissue (preferentially visceral)
- 40–60% increase in FFA release (AJP study)
- Protein Synthesis
- mTOR pathway activation via IGF-1
- 4–6 days post-dose
- 7–10 days
- Skeletal muscle myocytes
- 30–50% increase in fractional synthesis rate (JAP study)
- Mitochondrial Biogenesis
- PGC-1α upregulation via GH and IGF-1
- 5–7 days post-dose
- 14–21 days
- Skeletal muscle, hepatic tissue
- 25–35% increase in mitochondrial density (Cell Metabolism study)
- Professional Assessment
- CJC-1295 downstream effects are temporally staggered. Measuring outcomes before day 5 captures GH release but misses the metabolic consequences that define the peptide's utility in body composition and recovery research.