Source comparison
CJC-1295 no DAC Administration: Fasted vs Fed State Comparison
Fasted (>2 hours post-meal) 180–220% 15–30 Low (<5 μIU/mL) Minimal Gold standard for research protocols. Maximises receptor availability and downstream signaling Fed (<1 hour post-meal) 90–110% 20–40 Elevated (15–40 μIU/mL) High GH response blunted by 40–50%.
This comparison does not assign a generated winner or score.
- Fasted (>2 hours post-meal)
- 180–220%
- 15–30
- Low (<5 μIU/mL)
- Minimal
- Gold standard for research protocols. Maximises receptor availability and downstream signaling
- Fed (<1 hour post-meal)
- 90–110%
- 20–40
- Elevated (15–40 μIU/mL)
- High
- GH response blunted by 40–50%. Insulin-driven somatostatin upregulation blocks GHRH receptor activation
- Post-protein meal
- 100–130%
- 25–45
- Moderate (10–20 μIU/mL)
- Moderate
- Amino acids (especially arginine) may slightly augment GH release, but insulin effect dominates
- Post-high-fat meal
- 95–115%
- 30–50
- Low-moderate (8–15 μIU/mL)
- Moderate-high
- Delayed gastric emptying prolongs insulin exposure. Net effect still suppressive despite lower initial insulin spike
- With caffeine (fasted)
- 190–240%
- 12–25
- Caffeine may enhance catecholamine-mediated GH release. Synergistic effect with CJC-1295 no DAC
- Professional Assessment
- Fasted administration 2+ hours post-meal consistently produces 2× the GH response of fed-state dosing. Meal composition matters less than timing. Even 'clean' meals suppress GH if consumed within the critical 2-hour window.