Source comparison
CJC-1295 No DAC: Formulation Comparison
Plasma Half-Life 26–30 minutes 6–8 days 6–7 minutes No-DAC balances extended activity beyond native GHRH without the multi-day suppression of pulsatile feedback that DAC variants cause Peak GH Response Time 15–30 minutes 4–6 hours 10–15 minutes Rapid onset mat
This comparison does not assign a generated winner or score.
- Plasma Half-Life
- 26–30 minutes
- 6–8 days
- 6–7 minutes
- No-DAC balances extended activity beyond native GHRH without the multi-day suppression of pulsatile feedback that DAC variants cause
- Peak GH Response Time
- 15–30 minutes
- 4–6 hours
- 10–15 minutes
- Rapid onset matches endogenous pulse timing, allowing alignment with physiological GH release windows (sleep, fasted training)
- GH Pulse Amplitude Increase
- 200–300% above baseline
- 150–200% sustained elevation
- 100% (baseline reference)
- Higher amplitude per pulse than DAC, but requires repeated dosing to match cumulative AUC. Trade-off is feedback preservation vs convenience
- Receptor Occupancy Duration
- <2 hours
- 5–7 days continuous
- <30 minutes
- Short occupancy prevents receptor downregulation and maintains hypothalamic responsiveness to physiological GHRH stimuli
- Albumin Binding
- None (direct renal clearance)
- Covalent via maleimidopropionic acid
- None
- Absence of albumin binding accelerates clearance, limiting off-target effects but requiring more frequent administration for sustained protocols
- Administration Frequency (Research Protocols)
- 2–3× daily for multi-day studies
- Once every 5–7 days
- Continuous IV infusion required
- No-DAC suits pulsatile protocols; DAC suits long-term steady-state studies. Choice depends on research question, not 'better or worse'