Source comparison
CJC-1295 No DAC & Ipamorelin: Mechanism Comparison
CJC-1295 no DAC 30 minutes GHRH analog. Binds to pituitary GHRH receptors to extend endogenous GH pulse duration Extends natural pulse from 30 min to ~3 hours Minimal to none 20–35% at 100mcg dose Best for extending pulse duration without receptor desensitizat
This comparison does not assign a generated winner or score.
- CJC-1295 no DAC
- 30 minutes
- GHRH analog. Binds to pituitary GHRH receptors to extend endogenous GH pulse duration
- Extends natural pulse from 30 min to ~3 hours
- Minimal to none
- 20–35% at 100mcg dose
- Best for extending pulse duration without receptor desensitization; requires frequent dosing (2–3x/week minimum)
- Ipamorelin
- 2 hours
- Ghrelin mimetic. Selectively stimulates GH release via growth hormone secretagogue receptor (GHS-R1a)
- Generates 60–90 min pulse
- None (highly selective)
- 15–25% at 100mcg dose
- Safest secretagogue profile; no hunger signaling or cortisol spike; ideal for combination protocols
- CJC-1295 DAC
- 6–8 days
- GHRH analog with drug affinity complex for extended half-life
- Continuous low-level GH elevation
- Moderate cortisol increase after 4+ weeks
- 40–60% sustained
- Avoids pulsatility entirely. Not recommended due to receptor downregulation and blunted natural GH response
- GHRP-6
- 20 minutes
- Non-selective ghrelin mimetic
- 45–60 min pulse
- Moderate cortisol and prolactin increase
- 18–30% at 100mcg dose
- Strong GH response but triggers significant hunger via ghrelin pathway; cortisol elevation limits long-term use