Source comparison
CJC-1295 No DAC & Ipamorelin: Receptor Mechanism Comparison
CJC-1295 No DAC GHRH receptor (GHRHR) Gs cAMP → PKA → CREB → GH transcription + vesicle priming 15–20 minutes High (60–80% suppression under elevated SST tone) None Ipamorelin Ghrelin receptor (GHS-R1a) Gq PLC → IP3 → calcium mobilization → vesicle fusion 3–5
This comparison does not assign a generated winner or score.
- CJC-1295 No DAC
- GHRH receptor (GHRHR)
- Gs
- cAMP → PKA → CREB → GH transcription + vesicle priming
- 15–20 minutes
- High (60–80% suppression under elevated SST tone)
- None
- Ipamorelin
- Ghrelin receptor (GHS-R1a)
- Gq
- PLC → IP3 → calcium mobilization → vesicle fusion
- 3–5 minutes
- Low (calcium pathway bypasses cAMP inhibition)
- None (>100× selectivity vs ACTH/PRL pathways)
- Combined (CJC + IPA)
- GHRHR + GHS-R1a
- Gs + Gq
- Convergent vesicle priming + calcium-triggered release
- 10–15 minutes
- Minimal (ipamorelin overrides SST brake)