Source comparison
CJC-1295 No DAC Mechanism of Action Detailed: Comparison
Plasma Half-Life ~30 minutes 6–8 days <7 minutes No DAC preserves pulsatile physiology; DAC trades pulse fidelity for convenience Receptor Occupancy Pattern Transient (90–120 min) Continuous (168+ hours) Transient (<15 min) Transient occupancy prevents recepto
This comparison does not assign a generated winner or score.
- Plasma Half-Life
- ~30 minutes
- 6–8 days
- <7 minutes
- No DAC preserves pulsatile physiology; DAC trades pulse fidelity for convenience
- Receptor Occupancy Pattern
- Transient (90–120 min)
- Continuous (168+ hours)
- Transient (<15 min)
- Transient occupancy prevents receptor downregulation across multi-week protocols
- GH Pulse Amplification
- 200–300% above baseline
- 50–80% sustained elevation
- 100–150% (reference)
- No DAC produces higher peak amplitude; DAC raises baseline without pulse distinction
- Dosing Frequency
- 1–3x daily
- Once weekly
- Continuous endogenous
- No DAC requires protocol adherence; DAC simplifies but risks tolerance
- Somatostatin Sensitivity
- Fully responsive
- Partially overridden
- No DAC respects hypothalamic gating; DAC disrupts feedback loop
- Receptor Desensitisation Risk
- Minimal (clears between pulses)
- High (continuous occupancy)
- None (physiological rhythm)
- Receptor recycling time between doses is critical for sustained efficacy