Source comparison
CJC-1295 No DAC Natural GH Rhythm Complete Guide 2026: Comparison Table
Half-Life 2–4 hours (subcutaneous) No-DAC clears fastest; rhGH intermediate; DAC persists across days Endogenous GH Suppression None (amplifies natural pulses) Minimal (modest negative feedback) Complete (shuts down pituitary GH secretion) No-DAC preserves end
This comparison does not assign a generated winner or score.
- Half-Life
- 2–4 hours (subcutaneous)
- No-DAC clears fastest; rhGH intermediate; DAC persists across days
- Endogenous GH Suppression
- None (amplifies natural pulses)
- Minimal (modest negative feedback)
- Complete (shuts down pituitary GH secretion)
- No-DAC preserves endogenous production; rhGH eliminates it
- Receptor Desensitisation Timeline
- None observed (transient agonism)
- 8–12 weeks (progressive blunting)
- N/A (replaces endogenous signal)
- No-DAC maintains sensitivity indefinitely; DAC shows diminishing returns
- IGF-1 Elevation Pattern
- Pulsatile increase (mirrors GH pulses)
- Sustained moderate increase
- Sustained high increase
- rhGH creates highest IGF-1; no-DAC creates physiological pattern
- Cost per Week (Research-Grade)
- $15–$30 (daily dosing)
- $20–$40 (weekly dosing)
- $200–$600 (daily dosing)
- No-DAC and DAC are cost-effective; rhGH is 10–20x more expensive