Source comparison
CJC-1295 No DAC Primary Pathway Mechanism: Peptide Comparison
CJC-1295 no DAC (Mod GRF) GHRH receptor (pituitary somatotrophs) ~30 minutes Sharp pulse, returns to baseline in 90–120 min Minimal. Preserves endogenous pulsatility 1–3× daily at circadian windows CJC-1295 with DAC 6–8 days Sustained elevation with blunted pu
This comparison does not assign a generated winner or score.
- CJC-1295 no DAC (Mod GRF)
- GHRH receptor (pituitary somatotrophs)
- ~30 minutes
- Sharp pulse, returns to baseline in 90–120 min
- Minimal. Preserves endogenous pulsatility
- 1–3× daily at circadian windows
- CJC-1295 with DAC
- 6–8 days
- Sustained elevation with blunted pulses
- High. Suppresses natural GHRH rhythm after 4–6 weeks
- 1–2× weekly
- GHRP-2 / GHRP-6
- Ghrelin receptor (GHS-R1a, hypothalamus + pituitary)
- 20–30 minutes
- Pulse, synergizes with GHRH analogues
- Low when dosed intermittently
- 1–3× daily, often stacked with Mod GRF
- Ipamorelin
- Ghrelin receptor (GHS-R1a)
- 2 hours
- Pulse, more selective than GHRP-2/6
- Low. Minimal ghrelin side effects
- 1–2× daily
- Sermorelin
- GHRH receptor (identical to Mod GRF mechanism)
- 10–20 minutes
- Pulse, shortest-acting GHRH analogue
- Minimal. Clears faster than Mod GRF
- 1–2× daily (less stable than Mod GRF)
- Bottom Line
- CJC-1295 no DAC offers the ideal balance: GHRH receptor specificity with a half-life short enough to preserve natural feedback but long enough (vs sermorelin) to produce robust, reproducible pulses when dosed at physiological windows.