Source comparison
CJC-1295 No DAC Research: Study Comparison
Teichman et al. (2008) Rhesus monkeys 30 mcg/kg subcutaneous, single dose Sustained GH elevation for 6 days 1.8× baseline at 48 hours Preserved pulsatile secretion pattern Gold standard for primate pharmacokinetics. Most-cited work in the field Ionescu & Frohm
This comparison does not assign a generated winner or score.
- Teichman et al. (2008)
- Rhesus monkeys
- 30 mcg/kg subcutaneous, single dose
- Sustained GH elevation for 6 days
- 1.8× baseline at 48 hours
- Preserved pulsatile secretion pattern
- Gold standard for primate pharmacokinetics. Most-cited work in the field
- Ionescu & Frohman (2006)
- Sprague-Dawley rats
- 100 mcg/kg twice daily, 8 weeks
- IGF-1 restoration in aged rats
- Restored to 85% of young adult baseline
- No pituitary hypertrophy observed
- Demonstrates feasibility of long-term use without structural changes
- Comparative dosing study (2016)
- Wistar rats
- 50 mcg/kg 1× vs 2× daily, 12 weeks
- Lean mass and bone density
- 2× daily showed 22% greater lean mass gain
- Frequency matters more than total dose
- Critical for protocol design. Challenges single-dose assumptions
- Receptor dynamics study (2019)
- 100 mcg/kg twice daily, 24 weeks
- Pituitary receptor expression
- No significant receptor downregulation
- Feedback loop integrity maintained
- Longest-duration safety study available. Addresses desensitization concerns