Source comparison
CJC-1295 No DAC Signaling Pathway: Comparison
Half-life ~7–10 minutes 6–8 days <5 minutes No-DAC variant preserves natural clearance kinetics Receptor occupancy 30–60 minutes Continuous (5+ days) 10–30 minutes Sustained occupancy causes receptor downregulation GH release pattern Pulsatile (peaks at 15–30
This comparison does not assign a generated winner or score.
- Half-life
- ~7–10 minutes
- 6–8 days
- <5 minutes
- No-DAC variant preserves natural clearance kinetics
- Receptor occupancy
- 30–60 minutes
- Continuous (5+ days)
- 10–30 minutes
- Sustained occupancy causes receptor downregulation
- GH release pattern
- Pulsatile (peaks at 15–30 min, clears by 2–3 hrs)
- Sustained elevation
- Pulsatile
- Pulsatile release preserves hepatic IGF-1 sensitivity
- Signaling pathway
- Gαs → cAMP → PKA → Ca²⁺ influx
- Same pathway, prolonged
- Same pathway, physiological
- Identical intracellular cascade, different duration
- Synergy with GHRPs
- High (3–5× amplification)
- Moderate
- High
- Dual-pathway calcium mobilisation is most efficient
- Dosing frequency
- 2–3× daily for pulsatile effect
- 1–2× weekly
- Endogenous pulses every 3–5 hrs
- Mimicking natural rhythm requires multiple daily doses