Source comparison
CJC-1295 No DAC vs Mod GRF 1-29 — Key Differences
CJC-1295 No DAC and Modified GRF 1-29 are not two different peptides competing for your research protocol. They are the exact same 29-amino-acid GHRH analog sold under two names. The confusion stems from marketing nomenclature in the peptide research space, wh
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- CJC-1295 No DAC and Modified GRF 1-29 are not two different peptides competing for your research protocol. They are the exact same 29-amino-acid GHRH analog sold under two names. The confusion stems from marketing nomenclature in the peptide research space, where suppliers use different labels for identical molecular structures. The compound itself. A sermorelin derivative with four amino acid substitutions that extend stability while maintaining pulsatile GH secretion. Has a 30-minute plasma half-life and works through GHRH receptor activation in the anterior pituitary.
- Our team has sourced peptides for research applications across hundreds of labs. The 'No DAC' versus 'Mod GRF' distinction causes more protocol errors than any other naming issue in growth hormone research. Labs order both thinking they're stacking two compounds when they're administering duplicate doses of the same peptide.
- What's the difference between CJC-1295 No DAC and Mod GRF 1-29?
- There is no pharmacological difference. CJC-1295 No DAC and Mod GRF 1-29 are the same peptide with identical amino acid sequences, mechanisms of action, and half-lives. Both are tetrasubstituted GHRH analogs (positions 2, 8, 15, 27) that trigger pulsatile growth hormone release for approximately 30 minutes after subcutaneous administration. The 'No DAC' label distinguishes this compound from CJC-1295 DAC (Drug Affinity Complex), which contains an added lysine-maleimidoproprionic acid group extending half-life to 6–8 days.
- The naming split happened because 'CJC-1295' originally referred to the DAC version in early clinical trials. When researchers wanted the short-acting GHRH analog without the half-life extension, suppliers began labeling it 'CJC-1295 No DAC' to differentiate from the DAC version. Simultaneously, other suppliers used 'Modified GRF 1-29'. A more technically accurate name referencing the four modifications to the original GRF 1-29 (sermorelin) structure. Both names describe the exact same 29-amino-acid peptide. This article covers the molecular structure, the DAC modification that creates the actual distinction, how dosing protocols differ when DAC is present, and what preparation mistakes turn effective compounds into degraded solutions.