Source comparison
CJC-1295 No DAC vs. Native GHRH vs. Other Analogs — In Vitro Performance Comparison
Plasma Half-Life (in vitro surrogate) 7–10 minutes 20–30 minutes 6–8 days (not applicable in vitro) 8–12 minutes 26–38 minutes CJC-1295 No DAC offers the ideal balance for controlled pulse experiments. Long enough to saturate receptors but short enough to clea
This comparison does not assign a generated winner or score.
- Plasma Half-Life (in vitro surrogate)
- 7–10 minutes
- 20–30 minutes
- 6–8 days (not applicable in vitro)
- 8–12 minutes
- 26–38 minutes
- CJC-1295 No DAC offers the ideal balance for controlled pulse experiments. Long enough to saturate receptors but short enough to clear between treatments.
- Receptor Binding Affinity (Kd)
- 1–3 nM
- 0.5–2.0 nM
- 2–5 nM
- CJC-1295 No DAC shows marginally higher affinity than native GHRH due to amino acid substitutions at positions 2, 8, 15, and 27. Enough to improve signal consistency without changing receptor selectivity.
- Resistance to DPP-IV Degradation
- No
- Yes
- Partial
- Unmodified GHRH and Sermorelin are rapidly cleaved at the N-terminus by DPP-IV present in serum-containing culture media. CJC-1295 No DAC's D-Ala2 substitution prevents this, maintaining peptide integrity throughout the assay window.
- Suitability for Pulsatile Dosing Studies
- Moderate
- Excellent
- Poor
- Only CJC-1295 No DAC and native GHRH clear fast enough to permit wash-out and re-stimulation protocols. The DAC version's multi-day half-life makes it unsuitable for time-course experiments.
- Cost per Experiment (per 1 mg peptide)
- $120–$180
- $90–$140
- $100–$150
- $80–$120
- $200–$300
- CJC-1295 No DAC sits in the middle cost bracket. Cheaper than specialty analogs like Tesamorelin but slightly more expensive than Sermorelin due to synthesis complexity. For labs running high-throughput screens, cost per data point matters.
- Receptor Desensitization Risk
- Low
- Very Low
- High
- Sustained agonist exposure (DAC version) downregulates GHRHR expression. Studies show 40–60% reduction in receptor density after 48 hours of continuous stimulation. No DAC avoids this entirely.