Source comparison
CJC-1295 vs. Sermorelin | Comprehensive Comparison
Both CJC-1295 and sermorelin are 29 amino acid peptide analogs of GHRH, activating the corresponding receptors in the anterior pituitary gland to stimulate the synthesis of GH. Yet, the two peptides differ significantly in their half-life, resulting in differe
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- Both CJC-1295 and sermorelin are 29 amino acid peptide analogs of GHRH, activating the corresponding receptors in the anterior pituitary gland to stimulate the synthesis of GH.
- Yet, the two peptides differ significantly in their half-life, resulting in different GH responses following administration.
- Physiological GH secretion occurs in pulses, which can reach about 10ng/ml in men and 14ng/ml in women [11]. Both CJC-1295 and sermorelin appear to increase GH levels produced during pulses without causing the hormone to reach supraphysiological levels. Pulse frequency remains unaffected.
- Here are some of the most interesting studies regarding the GH-boosting potential of each peptide:
- CJC-1295 has been administered to healthy young and middle-aged study volunteers as a single dose, ranging between 30mcg/kg and 250mcg/kg of body weight. The peptide increased total GH levels while preserving pulsatile secretion, and peak levels remained within physiological limits. A 60mcg/kg dose led to a roughly 150% increase in mean GH levels.
- A single 250mcg/kg dose led to an over 300% increase in GH AUC. The 60mcg/kg dose was also tested as a biweekly dosage (applied twice in 14 days), and the protocol led to a sustained increase in mean GH levels by the 28th day [12].
- CJC-1295, injected as a single injection in another study, was effective at increasing GH even one week after application in 20-40 y.o. men. Study authors reported that the mean (12-hour) GH levels, measured seven days after peptide injection, were 46% higher than mean pretreatment levels [13].
- Sermorelin was studied over six weeks in 11 elderly males receiving 2mg/daily as subcutaneous injections. This treatment boosted the volunteers’ mean GH levels by 82%, as indicated by AUC measurements. Elevated GH concentrations remained for about two hours after each injection [14].
- Sermorelin as a twice-daily injection (morning and evening) for four weeks led to a significant increase in GH levels in young and elderly men. More specifically, 2mg/daily sermorelin helped elderly subjects achieve a 64% increase in GH AUC, attaining GH levels similar to those in young, untreated, healthy males. The 4-hour GH AUC was higher following the evening injection compared to the morning injection [15].