Clinical Outcomes Versus Biomarker Improvements
A biomarker, such as mitochondrial respiration or ATP production, may help explain mechanism. A clinical outcome, such as walking distance, heart function, hospitalization, fatigue improvement, or survival, determines whether a therapy helps patients in a mean
This comparison does not assign a generated winner or score.
- A biomarker, such as mitochondrial respiration or ATP production, may help explain mechanism. A clinical outcome, such as walking distance, heart function, hospitalization, fatigue improvement, or survival, determines whether a therapy helps patients in a meaningful way 20.
- For SS-31, this distinction is essential. Mitochondrial function with SS-31 may improve in some models, but clinical outcomes require direct evidence.