Source comparison
Comparison: MK-677 Clearance vs Other Growth Hormone Secretagogues
MK-677 (Ibutamoren) 4.7 hours 10–21 days (urine) 2–4 weeks post-dose Longest secondary effect window. IGF-1 stays elevated well after parent compound clears GHRP-2 0.5–1 hour 24–48 hours (plasma) 3–7 days post-dose Rapid clearance but requires daily dosing. De
This comparison does not assign a generated winner or score.
- MK-677 (Ibutamoren)
- 4.7 hours
- 10–21 days (urine)
- 2–4 weeks post-dose
- Longest secondary effect window. IGF-1 stays elevated well after parent compound clears
- GHRP-2
- 0.5–1 hour
- 24–48 hours (plasma)
- 3–7 days post-dose
- Rapid clearance but requires daily dosing. Detection windows are shortest among GH secretagogues
- GHRP-6
- 0.5–1.2 hours
- 36–60 hours (plasma)
- 4–10 days post-dose
- Similar kinetics to GHRP-2 but slightly longer metabolite tail due to lipophilicity
- CJC-1295 (DAC)
- 6–8 days
- 21–35 days (plasma)
- 4–6 weeks post-dose
- Drug Affinity Complex extends both parent and metabolite clearance. Longest detection of any peptide GH secretagogue
- Hexarelin
- 1.2–1.8 hours
- 48–96 hours (urine)
- 7–14 days post-dose
- Mid-range clearance. Faster than MK-677 but slower desensitisation makes chronic use problematic