Source comparison
Comparison of Muscle Atrophy Signaling Effects
MuRF1 mRNA Elevated Reduced in some models Moderate MAFbx mRNA Trend toward reduction Limited FOXO3a nuclear localization Increased Reduced (AMPK-dependent) SMAD2/3 phosphorylation Modest reduction in some studies Limited/preliminary Myostatin protein levels E
This comparison does not assign a generated winner or score.
- MuRF1 mRNA
- Elevated
- Reduced in some models
- Moderate
- MAFbx mRNA
- Trend toward reduction
- Limited
- FOXO3a nuclear localization
- Increased
- Reduced (AMPK-dependent)
- SMAD2/3 phosphorylation
- Modest reduction in some studies
- Limited/preliminary
- Myostatin protein levels
- Elevated in atrophy
- Mixed findings
- Inconsistent
- Myotube diameter
- Reduced (atrophy)
- Partially preserved
- mTORC1 activity
- Variable
- May be reduced (AMPK effect)
- Context-dependent