Source comparison
Comparison Table: CJC-1295 No DAC vs Ipamorelin Receptor Mechanisms
CJC-1295 No DAC GHRH receptor (pituitary somatotrophs) Gs (stimulatory) Adenylyl cyclase → cAMP → PKA → voltage-gated Ca²⁺ channels Extracellular influx 6–8 days 2.5–3.5× baseline High selectivity for GH; minimal cortisol or prolactin elevation Provides sustai
This comparison does not assign a generated winner or score.
- CJC-1295 No DAC
- GHRH receptor (pituitary somatotrophs)
- Gs (stimulatory)
- Adenylyl cyclase → cAMP → PKA → voltage-gated Ca²⁺ channels
- Extracellular influx
- 6–8 days
- 2.5–3.5× baseline
- High selectivity for GH; minimal cortisol or prolactin elevation
- Provides sustained GHRH receptor activation without continuous receptor saturation. Ideal for preserving pulsatile GH secretion over multi-week protocols
- Ipamorelin
- GHS-R1a (ghrelin receptor, pituitary somatotrophs)
- Gq (activating PLC)
- Phospholipase C → IP3 + DAG → intracellular Ca²⁺ release
- Endoplasmic reticulum stores
- 2–3 hours
- 2.0–2.8× baseline
- Highly selective for GHS-R1a; no significant appetite or gastric motility effects
- Delivers ghrelin-mimetic signaling without off-target appetite stimulation. Mobilizes reserve pool GH vesicles that GHRH alone cannot access
- Combined Protocol
- Both GHRH and GHS-R1a
- Dual Gs + Gq
- Convergent calcium mobilization (extracellular + intracellular sources)
- Both pathways
- Dependent on dosing schedule
- 6.0–8.5× baseline
- Synergistic with no additive side effect burden
- Dual-axis calcium signaling recruits both readily releasable and reserve vesicle pools. Produces amplitude increases that neither peptide achieves alone